BDBM227354 US9328106, 305

SMILES: C[C@H](O)c1cc(F)c(-c2nc(cs2)C(=O)Nc2cnn(C)c2[C@@H]2CC[C@@H](N)[C@H](F)CO2)c(F)c1

InChI Key: InChIKey=MXBZZFKFYONNMS-VCZPNBCRSA-N

Data: 1 KI

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 227354   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM227354 (US9328106, 305) Show SMILES C[C@H](O)c1cc(F)c(-c2nc(cs2)C(=O)Nc2cnn(C)c2[C@@H]2CC[C@@H](N)[C@H](F)CO2)c(F)c1 |r| Show InChI InChI=1S/C22H24F3N5O3S/c1-10(31)11-5-12(23)19(13(24)6-11)22-29-17(9-34-22)21(32)28-16-7-27-30(2)20(16)18-4-3-15(26)14(25)8-33-18/h5-7,9-10,14-15,18,31H,3-4,8,26H2,1-2H3,(H,28,32)/t10-,14+,15+,18-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.00800	-15.1	n/a	n/a	n/a	n/a	n/a	7.2	25
GENENTECH, INC. US Patent					Assay Description LC3K assay: PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Ch...				US Patent US9328106 (2016) BindingDB Entry DOI: 10.7270/Q29W0DBT
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