BDBM228680 US9346810, 125

SMILES: CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1cc2cn[nH]c2cn1

InChI Key: InChIKey=ZGNJQOOBOYTFHA-GFCCVEGCSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 228680   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM228680 (US9346810, 125) Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1cc2cn[nH]c2cn1 Show InChI InChI=1S/C17H18N8/c1-24(15-6-11-7-22-23-14(11)8-19-15)12-3-5-25(9-12)17-13-2-4-18-16(13)20-10-21-17/h2,4,6-8,10,12H,3,5,9H2,1H3,(H,22,23)(H,18,20,21)/t12-/m1/s1	PDB MMDB B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair
JAK1 (aa 866-1154) (Homo sapiens (Human))	BDBM228680 (US9346810, 125) Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1cc2cn[nH]c2cn1 Show InChI InChI=1S/C17H18N8/c1-24(15-6-11-7-22-23-14(11)8-19-15)12-3-5-25(9-12)17-13-2-4-18-16(13)20-10-21-17/h2,4,6-8,10,12H,3,5,9H2,1H3,(H,22,23)(H,18,20,21)/t12-/m1/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
					More data for this Ligand-Target Pair