BDBM230170 US9340500, I-014

SMILES: Cc1c(cc(-c2ccccc2)n1CCCN1CCNCC1)C(=O)Nc1cccc(c1)C(F)(F)F

InChI Key: InChIKey=WQBRGUPVUSOQNH-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 230170   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily V member 4 (TRPV4) (Homo sapiens (Human))	BDBM230170 (US9340500, I-014) Show SMILES Cc1c(cc(-c2ccccc2)n1CCCN1CCNCC1)C(=O)Nc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C26H29F3N4O/c1-19-23(25(34)31-22-10-5-9-21(17-22)26(27,28)29)18-24(20-7-3-2-4-8-20)33(19)14-6-13-32-15-11-30-12-16-32/h2-5,7-10,17-18,30H,6,11-16H2,1H3,(H,31,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	355	-9.15	n/a	n/a	n/a	n/a	n/a	n/a	37
SHIONOGI & CO., LTD. US Patent					Assay Description Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...				US Patent US9340500 (2016) BindingDB Entry DOI: 10.7270/Q2319TR3
					More data for this Ligand-Target Pair