BDBM230182 US9340500, I-026

SMILES: Cc1c(cc(-c2ccccc2)n1CCCNS(C)(=O)=O)C(=O)Nc1cccc(c1)C(F)(F)F

InChI Key: InChIKey=DINKGEARRXMYEP-UHFFFAOYSA-N

Data: 1 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 230182   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily V member 4 (TRPV4) (Homo sapiens (Human))	BDBM230182 (US9340500, I-026) Show SMILES Cc1c(cc(-c2ccccc2)n1CCCNS(C)(=O)=O)C(=O)Nc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C23H24F3N3O3S/c1-16-20(22(30)28-19-11-6-10-18(14-19)23(24,25)26)15-21(17-8-4-3-5-9-17)29(16)13-7-12-27-33(2,31)32/h3-6,8-11,14-15,27H,7,12-13H2,1-2H3,(H,28,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	427	-9.03	n/a	n/a	n/a	n/a	n/a	n/a	37
SHIONOGI & CO., LTD. US Patent					Assay Description Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...				US Patent US9340500 (2016) BindingDB Entry DOI: 10.7270/Q2319TR3
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4) (Homo sapiens (Human))	BDBM230182 (US9340500, I-026) Show SMILES Cc1c(cc(-c2ccccc2)n1CCCNS(C)(=O)=O)C(=O)Nc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C23H24F3N3O3S/c1-16-20(22(30)28-19-11-6-10-18(14-19)23(24,25)26)15-21(17-8-4-3-5-9-17)29(16)13-7-12-27-33(2,31)32/h3-6,8-11,14-15,27H,7,12-13H2,1-2H3,(H,28,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	860	n/a	n/a	n/a	n/a	n/a	37
SHIONOGI & CO., LTD. US Patent					Assay Description Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...				US Patent US9340500 (2016) BindingDB Entry DOI: 10.7270/Q2319TR3
					More data for this Ligand-Target Pair