BDBM230212 US9340500, I-056

SMILES: CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)C(=O)c1ccc(NC(C)=O)cc1

InChI Key: InChIKey=JQFUWSFUNNYOFY-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 230212   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily V member 4 (TRPV4) (Homo sapiens (Human))	BDBM230212 (US9340500, I-056) Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)C(=O)c1ccc(NC(C)=O)cc1 Show InChI InChI=1S/C32H31F3N4O3/c1-21-28(30(41)37-27-12-7-11-25(19-27)32(33,34)35)20-29(23-9-5-4-6-10-23)39(21)18-8-17-38(3)31(42)24-13-15-26(16-14-24)36-22(2)40/h4-7,9-16,19-20H,8,17-18H2,1-3H3,(H,36,40)(H,37,41)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	560	-8.87	n/a	n/a	n/a	n/a	n/a	n/a	37
SHIONOGI & CO., LTD. US Patent					Assay Description Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...				US Patent US9340500 (2016) BindingDB Entry DOI: 10.7270/Q2319TR3
					More data for this Ligand-Target Pair