BDBM230222 US9340500, I-066

SMILES: CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)C(=O)c1cnc2ccccc2n1

InChI Key: InChIKey=HRTXEOCBPQVOLO-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 230222   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily V member 4 (TRPV4) (Homo sapiens (Human))	BDBM230222 (US9340500, I-066) Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)C(=O)c1cnc2ccccc2n1 Show InChI InChI=1S/C32H28F3N5O2/c1-21-25(30(41)37-24-13-8-12-23(18-24)32(33,34)35)19-29(22-10-4-3-5-11-22)40(21)17-9-16-39(2)31(42)28-20-36-26-14-6-7-15-27(26)38-28/h3-8,10-15,18-20H,9,16-17H2,1-2H3,(H,37,41)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	662	-8.76	n/a	n/a	n/a	n/a	n/a	n/a	37
SHIONOGI & CO., LTD. US Patent					Assay Description Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...				US Patent US9340500 (2016) BindingDB Entry DOI: 10.7270/Q2319TR3
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