BDBM230228 US9340500, I-072

SMILES: Cc1c(cc(C2CCCCC2)n1CCCN1CCOCC1)C(=O)Nc1cccc(c1)C(F)(F)F

InChI Key: InChIKey=CKUBDISBCAFOFK-UHFFFAOYSA-N

Data: 1 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 230228   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily V member 4 (TRPV4) (Homo sapiens (Human))	BDBM230228 (US9340500, I-072) Show SMILES Cc1c(cc(C2CCCCC2)n1CCCN1CCOCC1)C(=O)Nc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C26H34F3N3O2/c1-19-23(25(33)30-22-10-5-9-21(17-22)26(27,28)29)18-24(20-7-3-2-4-8-20)32(19)12-6-11-31-13-15-34-16-14-31/h5,9-10,17-18,20H,2-4,6-8,11-16H2,1H3,(H,30,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	21	-10.9	45	n/a	n/a	n/a	n/a	n/a	37
SHIONOGI & CO., LTD. US Patent					Assay Description Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...				US Patent US9340500 (2016) BindingDB Entry DOI: 10.7270/Q2319TR3
					More data for this Ligand-Target Pair