BDBM230231 US9340500, I-075

SMILES: Cc1c(cc(C2CCN(CC2)C(=O)OCc2ccccc2)n1CCCN1CCOCC1)C(=O)Nc1cccc(c1)C(F)(F)F

InChI Key: InChIKey=DGBAWOXGLXNPSZ-UHFFFAOYSA-N

Data: 1 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 230231   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily V member 4 (TRPV4) (Homo sapiens (Human))	BDBM230231 (US9340500, I-075) Show SMILES Cc1c(cc(C2CCN(CC2)C(=O)OCc2ccccc2)n1CCCN1CCOCC1)C(=O)Nc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C33H39F3N4O4/c1-24-29(31(41)37-28-10-5-9-27(21-28)33(34,35)36)22-30(40(24)14-6-13-38-17-19-43-20-18-38)26-11-15-39(16-12-26)32(42)44-23-25-7-3-2-4-8-25/h2-5,7-10,21-22,26H,6,11-20,23H2,1H3,(H,37,41)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	130	-9.77	270	n/a	n/a	n/a	n/a	n/a	37
SHIONOGI & CO., LTD. US Patent					Assay Description Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...				US Patent US9340500 (2016) BindingDB Entry DOI: 10.7270/Q2319TR3
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