BDBM230264 US9340500, I-108

SMILES: Cc1c(cc(n1CC(C)(C)CN1CCOCC1)C(C)(C)C)C(=O)Nc1cccc(c1)C(F)(F)F

InChI Key: InChIKey=LIBWFSURRBLBIS-UHFFFAOYSA-N

Data: 1 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 230264   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily V member 4 (TRPV4) (Homo sapiens (Human))	BDBM230264 (US9340500, I-108) Show SMILES Cc1c(cc(n1CC(C)(C)CN1CCOCC1)C(C)(C)C)C(=O)Nc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C26H36F3N3O2/c1-18-21(23(33)30-20-9-7-8-19(14-20)26(27,28)29)15-22(24(2,3)4)32(18)17-25(5,6)16-31-10-12-34-13-11-31/h7-9,14-15H,10-13,16-17H2,1-6H3,(H,30,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	170	-9.60	540	n/a	n/a	n/a	n/a	n/a	37
SHIONOGI & CO., LTD. US Patent					Assay Description Test Example 1: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) In the day be...				US Patent US9340500 (2016) BindingDB Entry DOI: 10.7270/Q2319TR3
					More data for this Ligand-Target Pair