null

SMILES: Cn1cc(Br)nc1C(=O)Nc1ccc(F)c(c1)[C@@]1(C)N=C(N)[C@@](C)(F)CC1(F)F

InChI Key: InChIKey=HOESHHMMCCAKCR-DLBZAZTESA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 234456   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Beta-secretase 1 (Homo sapiens (Human))	BDBM234456 (US10004738, 9 | US9353084, 9) Show SMILES Cn1cc(Br)nc1C(=O)Nc1ccc(F)c(c1)[C@@]1(C)N=C(N)[C@@](C)(F)CC1(F)F |r,t:21| Show InChI InChI=1S/C18H18BrF4N5O/c1-16(21)8-18(22,23)17(2,27-15(16)24)10-6-9(4-5-11(10)20)25-14(29)13-26-12(19)7-28(13)3/h4-7H,8H2,1-3H3,(H2,24,27)(H,25,29)/t16-,17+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...				J Med Chem 52: 6621-36 (2009) BindingDB Entry DOI: 10.7270/Q2B85BGS
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM234456 (US10004738, 9 | US9353084, 9) Show SMILES Cn1cc(Br)nc1C(=O)Nc1ccc(F)c(c1)[C@@]1(C)N=C(N)[C@@](C)(F)CC1(F)F |r,t:21| Show InChI InChI=1S/C18H18BrF4N5O/c1-16(21)8-18(22,23)17(2,27-15(16)24)10-6-9(4-5-11(10)20)25-14(29)13-26-12(19)7-28(13)3/h4-7H,8H2,1-3H3,(H2,24,27)(H,25,29)/t16-,17+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	100	n/a	n/a	n/a	n/a	n/a	n/a	4.5	n/a
H. Lundbeck A/S US Patent					Assay Description The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...				US Patent US9353084 (2016) BindingDB Entry DOI: 10.7270/Q2MG7NDX
					More data for this Ligand-Target Pair