BDBM234483 US10004738, 36::US9353084, 36

SMILES: C[C@@]1(F)CC(F)(F)[C@](C)(N=C1N)c1cc(NC(=O)c2nccs2)ccc1F

InChI Key: InChIKey=PZMYIHWMYVSDEE-HZPDHXFCSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 234483   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Beta-secretase 1 (Homo sapiens (Human))	BDBM234483 (US10004738, 36 | US9353084, 36) Show SMILES C[C@@]1(F)CC(F)(F)[C@](C)(N=C1N)c1cc(NC(=O)c2nccs2)ccc1F |r,c:9| Show InChI InChI=1S/C17H16F4N4OS/c1-15(19)8-17(20,21)16(2,25-14(15)22)10-7-9(3-4-11(10)18)24-12(26)13-23-5-6-27-13/h3-7H,8H2,1-2H3,(H2,22,25)(H,24,26)/t15-,16-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	390	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...				J Med Chem 52: 6621-36 (2009) BindingDB Entry DOI: 10.7270/Q2B85BGS
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM234483 (US10004738, 36 | US9353084, 36) Show SMILES C[C@@]1(F)CC(F)(F)[C@](C)(N=C1N)c1cc(NC(=O)c2nccs2)ccc1F |r,c:9| Show InChI InChI=1S/C17H16F4N4OS/c1-15(19)8-17(20,21)16(2,25-14(15)22)10-7-9(3-4-11(10)18)24-12(26)13-23-5-6-27-13/h3-7H,8H2,1-2H3,(H2,22,25)(H,24,26)/t15-,16-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	390	n/a	n/a	n/a	n/a	n/a	n/a	4.5	n/a
H. Lundbeck A/S US Patent					Assay Description The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...				US Patent US9353084 (2016) BindingDB Entry DOI: 10.7270/Q2MG7NDX
					More data for this Ligand-Target Pair