BDBM236640 US9388139, 8
SMILES: COc1ccc(cc1)C1CC(=NN1c1ccc(cc1)C(O)=O)c1ccccc1OC
InChI Key: InChIKey=SGXGRYNXXLPGLY-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM236640 (US9388139, 8) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
German University; Southern Research Institute US Patent | Assay Description PDE activity was measured using the IMAP fluorescence polarization assay (Molecular Devices) in which binding of hydrolyzed cyclic nucleotide substra... | US Patent US9388139 (2016) BindingDB Entry DOI: 10.7270/Q2GF0SFS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 2 (Homo sapiens (Human)) | BDBM236640 (US9388139, 8) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
German University; Southern Research Institute US Patent | Assay Description The activities of COX-1 and COX-2 were measured after the addition of arachidonic acid and incubation at 25° C. for 5 min by absorbance at 590 nm as ... | US Patent US9388139 (2016) BindingDB Entry DOI: 10.7270/Q2GF0SFS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 1 (Homo sapiens (Human)) | BDBM236640 (US9388139, 8) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
German University; Southern Research Institute US Patent | Assay Description The activities of COX-1 and COX-2 were measured after the addition of arachidonic acid and incubation at 25° C. for 5 min by absorbance at 590 nm as ... | US Patent US9388139 (2016) BindingDB Entry DOI: 10.7270/Q2GF0SFS | |||||||||||
More data for this Ligand-Target Pair |