BDBM237887 US9394282, 9-22

SMILES: NC(=O)c1cn(nc1Nc1cnc2cc(Cl)ccc2c1)[C@H]1COCC[C@@H]1C#N

InChI Key: InChIKey=TYTFKEFIBRFXFB-PXAZEXFGSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 237887   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM237887 (US9394282, 9-22) Show SMILES NC(=O)c1cn(nc1Nc1cnc2cc(Cl)ccc2c1)[C@H]1COCC[C@@H]1C#N |r| Show InChI InChI=1S/C19H17ClN6O2/c20-13-2-1-11-5-14(8-23-16(11)6-13)24-19-15(18(22)27)9-26(25-19)17-10-28-4-3-12(17)7-21/h1-2,5-6,8-9,12,17H,3-4,10H2,(H2,22,27)(H,24,25)/t12-,17+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...				US Patent US9394282 (2016) BindingDB Entry DOI: 10.7270/Q2J10233
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM237887 (US9394282, 9-22) Show SMILES NC(=O)c1cn(nc1Nc1cnc2cc(Cl)ccc2c1)[C@H]1COCC[C@@H]1C#N |r| Show InChI InChI=1S/C19H17ClN6O2/c20-13-2-1-11-5-14(8-23-16(11)6-13)24-19-15(18(22)27)9-26(25-19)17-10-28-4-3-12(17)7-21/h1-2,5-6,8-9,12,17H,3-4,10H2,(H2,22,27)(H,24,25)/t12-,17+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...				US Patent US9394282 (2016) BindingDB Entry DOI: 10.7270/Q2J10233
					More data for this Ligand-Target Pair