BDBM238695 US9394297, 358

SMILES: Cc1nc2cccc(-c3[nH]c4CNC(=O)c4c3Cl)c2nc1NC1(C)CC1

InChI Key: InChIKey=CTADVIUFFUGUBU-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 238695   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM238695 (US9394297, 358) Show SMILES Cc1nc2cccc(-c3[nH]c4CNC(=O)c4c3Cl)c2nc1NC1(C)CC1 Show InChI InChI=1S/C19H18ClN5O/c1-9-17(25-19(2)6-7-19)24-15-10(4-3-5-11(15)22-9)16-14(20)13-12(23-16)8-21-18(13)26/h3-5,23H,6-8H2,1-2H3,(H,21,26)(H,24,25)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0783	n/a	n/a	n/a	n/a	7.0	22
AMGEN INC. US Patent					Assay Description The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...				US Patent US9394297 (2016) BindingDB Entry DOI: 10.7270/Q2G44P78
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM238695 (US9394297, 358) Show SMILES Cc1nc2cccc(-c3[nH]c4CNC(=O)c4c3Cl)c2nc1NC1(C)CC1 Show InChI InChI=1S/C19H18ClN5O/c1-9-17(25-19(2)6-7-19)24-15-10(4-3-5-11(15)22-9)16-14(20)13-12(23-16)8-21-18(13)26/h3-5,23H,6-8H2,1-2H3,(H,21,26)(H,24,25)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0339	n/a	n/a	n/a	n/a	7.0	22
AMGEN INC. US Patent					Assay Description The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...				US Patent US9394297 (2016) BindingDB Entry DOI: 10.7270/Q2G44P78
					More data for this Ligand-Target Pair