BDBM238767 US9394297, 451

SMILES: C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1nc(NC1(C)CC1)n(C)c2=O

InChI Key: InChIKey=QBCXALHYIBOFGV-SNVBAGLBSA-N

Data: 7 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 238767   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM238767 (US9394297, 451) Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1nc(NC1(C)CC1)n(C)c2=O Show InChI InChI=1S/C20H21N5O2/c1-10-15-13(17(26)21-10)9-14(22-15)11-5-4-6-12-16(11)23-19(25(3)18(12)27)24-20(2)7-8-20/h4-6,9-10,22H,7-8H2,1-3H3,(H,21,26)(H,23,24)/t10-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.238	n/a	n/a	n/a	n/a	7.0	22
AMGEN INC. US Patent					Assay Description The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...				US Patent US9394297 (2016) BindingDB Entry DOI: 10.7270/Q2G44P78
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM238767 (US9394297, 451) Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1nc(NC1(C)CC1)n(C)c2=O Show InChI InChI=1S/C20H21N5O2/c1-10-15-13(17(26)21-10)9-14(22-15)11-5-4-6-12-16(11)23-19(25(3)18(12)27)24-20(2)7-8-20/h4-6,9-10,22H,7-8H2,1-3H3,(H,21,26)(H,23,24)/t10-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.364	n/a	n/a	n/a	n/a	7.0	22
AMGEN INC. US Patent					Assay Description The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...				US Patent US9394297 (2016) BindingDB Entry DOI: 10.7270/Q2G44P78
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM238767 (US9394297, 451) Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1nc(NC1(C)CC1)n(C)c2=O Show InChI InChI=1S/C20H21N5O2/c1-10-15-13(17(26)21-10)9-14(22-15)11-5-4-6-12-16(11)23-19(25(3)18(12)27)24-20(2)7-8-20/h4-6,9-10,22H,7-8H2,1-3H3,(H,21,26)(H,23,24)/t10-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of full length recombinant PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues preincubated for 30 mins ...				J Med Chem 62: 1523-1540 (2019) Article DOI: 10.1021/acs.jmedchem.8b01733
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PIM (Homo sapiens (Human))	BDBM238767 (US9394297, 451) Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1nc(NC1(C)CC1)n(C)c2=O Show InChI InChI=1S/C20H21N5O2/c1-10-15-13(17(26)21-10)9-14(22-15)11-5-4-6-12-16(11)23-19(25(3)18(12)27)24-20(2)7-8-20/h4-6,9-10,22H,7-8H2,1-3H3,(H,21,26)(H,23,24)/t10-/m1/s1	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of pan Pim in human KMS-12-BM cells assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 residue after 110 m...				J Med Chem 59: 6407-30 (2016) Article DOI: 10.1021/acs.jmedchem.6b00610
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM238767 (US9394297, 451) Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1nc(NC1(C)CC1)n(C)c2=O Show InChI InChI=1S/C20H21N5O2/c1-10-15-13(17(26)21-10)9-14(22-15)11-5-4-6-12-16(11)23-19(25(3)18(12)27)24-20(2)7-8-20/h4-6,9-10,22H,7-8H2,1-3H3,(H,21,26)(H,23,24)/t10-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of full length recombinant Pim-1 (unknown origin) assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 resid...				J Med Chem 59: 6407-30 (2016) Article DOI: 10.1021/acs.jmedchem.6b00610
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM238767 (US9394297, 451) Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1nc(NC1(C)CC1)n(C)c2=O Show InChI InChI=1S/C20H21N5O2/c1-10-15-13(17(26)21-10)9-14(22-15)11-5-4-6-12-16(11)23-19(25(3)18(12)27)24-20(2)7-8-20/h4-6,9-10,22H,7-8H2,1-3H3,(H,21,26)(H,23,24)/t10-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of full length recombinant Pim-2 (unknown origin) assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 resid...				J Med Chem 59: 6407-30 (2016) Article DOI: 10.1021/acs.jmedchem.6b00610
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM238767 (US9394297, 451) Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1nc(NC1(C)CC1)n(C)c2=O Show InChI InChI=1S/C20H21N5O2/c1-10-15-13(17(26)21-10)9-14(22-15)11-5-4-6-12-16(11)23-19(25(3)18(12)27)24-20(2)7-8-20/h4-6,9-10,22H,7-8H2,1-3H3,(H,21,26)(H,23,24)/t10-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.380	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of full length recombinant PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues preincubated for 30 mins ...				J Med Chem 62: 1523-1540 (2019) Article DOI: 10.1021/acs.jmedchem.8b01733
					More data for this Ligand-Target Pair