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SMILES: COc1ccc(CO)cc1-c1nc2NC(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C

InChI Key: InChIKey=ZCELMKLYXSRUEB-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 238909   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Cellular tumor antigen p53 [18-26]/E3 ubiquitin-protein ligase Mdm2 [2-188]


(Homo sapiens (Human))		BDBM238909
PNG
(US9403827, 11)
Show SMILES COc1ccc(CO)cc1-c1nc2NC(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C
Show InChI InChI=1S/C30H30Cl2N4O3/c1-16(2)35-27-26(22-10-9-20(31)12-18(22)4)36(24-14-21(32)8-6-17(24)3)30(38)34-28(27)33-29(35)23-13-19(15-37)7-11-25(23)39-5/h6-14,16,26,37H,15H2,1-5H3,(H,34,38)
PDB
MMDB

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PC cid
PC sid
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US Patent
n/an/a 371n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
Assay 2: For selected compounds displaying IC50s between 0.05 and 5 nM on MDM2, a slightly modified assay is used with the following adaptations: 0.1...

US Patent US9403827 (2016)


BindingDB Entry DOI: 10.7270/Q2Z31XKH
More data for this
Ligand-Target Pair