BDBM238911 US9403827, 13

SMILES: COc1ccccc1-c1nc2NC(=O)N(C(c2n1C(C)C)c1ccc(cc1)C#N)c1cc(Cl)ccc1C

InChI Key: InChIKey=OUWACAFRBJFKML-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 238911   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
p53-MDM2 (Homo sapiens (Human))	BDBM238911 (US9403827, 13) Show SMILES COc1ccccc1-c1nc2NC(=O)N(C(c2n1C(C)C)c1ccc(cc1)C#N)c1cc(Cl)ccc1C Show InChI InChI=1S/C29H26ClN5O2/c1-17(2)34-26-25(20-12-10-19(16-31)11-13-20)35(23-15-21(30)14-9-18(23)3)29(36)33-27(26)32-28(34)22-7-5-6-8-24(22)37-4/h5-15,17,25H,1-4H3,(H,33,36)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	724	n/a	n/a	n/a	n/a	n/a	25
NOVARTIS AG US Patent					Assay Description Assay 2: For selected compounds displaying IC50s between 0.05 and 5 nM on MDM2, a slightly modified assay is used with the following adaptations: 0.1...				US Patent US9403827 (2016) BindingDB Entry DOI: 10.7270/Q2Z31XKH
					More data for this Ligand-Target Pair