BDBM238913 US9403827, 15

SMILES: COc1ncc(-c2nc3NC(=O)N(C(c3n2C(C)C)c2ccc(Cl)c(F)c2)c2ccc(F)c(Cl)c2)c(OC)n1

InChI Key: InChIKey=YGQRCKOQIJBCSF-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 238913   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
p53-MDM2 (Homo sapiens (Human))	BDBM238913 (US9403827, 15) Show SMILES COc1ncc(-c2nc3NC(=O)N(C(c3n2C(C)C)c2ccc(Cl)c(F)c2)c2ccc(F)c(Cl)c2)c(OC)n1 Show InChI InChI=1S/C26H22Cl2F2N6O3/c1-12(2)35-21-20(13-5-7-16(27)19(30)9-13)36(14-6-8-18(29)17(28)10-14)26(37)33-22(21)32-23(35)15-11-31-25(39-4)34-24(15)38-3/h5-12,20H,1-4H3,(H,33,37)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	451	n/a	n/a	n/a	n/a	n/a	25
NOVARTIS AG US Patent					Assay Description Assay 2: For selected compounds displaying IC50s between 0.05 and 5 nM on MDM2, a slightly modified assay is used with the following adaptations: 0.1...				US Patent US9403827 (2016) BindingDB Entry DOI: 10.7270/Q2Z31XKH
					More data for this Ligand-Target Pair