BDBM238920 US9403827, 22

SMILES: COc1nc(ncc1-c1nc2NC(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1)c1cc(Cl)cn(C)c1=O)N(C)C

InChI Key: InChIKey=UFHJUOJFZGVQSM-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 238920   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
p53-MDM2 (Homo sapiens (Human))	BDBM238920 (US9403827, 22) Show SMILES COc1nc(ncc1-c1nc2NC(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1)c1cc(Cl)cn(C)c1=O)N(C)C Show InChI InChI=1S/C27H28Cl2N8O3/c1-14(2)36-21-20(15-7-9-16(28)10-8-15)37(19-11-17(29)13-35(5)25(19)38)27(39)32-22(21)31-23(36)18-12-30-26(34(3)4)33-24(18)40-6/h7-14,20H,1-6H3,(H,32,39)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	587	n/a	n/a	n/a	n/a	n/a	25
NOVARTIS AG US Patent					Assay Description Assay 2: For selected compounds displaying IC50s between 0.05 and 5 nM on MDM2, a slightly modified assay is used with the following adaptations: 0.1...				US Patent US9403827 (2016) BindingDB Entry DOI: 10.7270/Q2Z31XKH
					More data for this Ligand-Target Pair