BDBM238921 US9403827, 23

SMILES: COc1nc(ncc1-c1nc2NC(=O)N(C(c2n1C(C)C)c1ccc(Cl)c(F)c1)c1ccc(F)c(Cl)c1)N(C)C

InChI Key: InChIKey=WHHGNSYEEPQONV-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 238921   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
p53-MDM2 (Homo sapiens (Human))	BDBM238921 (US9403827, 23) Show SMILES COc1nc(ncc1-c1nc2NC(=O)N(C(c2n1C(C)C)c1ccc(Cl)c(F)c1)c1ccc(F)c(Cl)c1)N(C)C Show InChI InChI=1S/C27H25Cl2F2N7O2/c1-13(2)37-22-21(14-6-8-17(28)20(31)10-14)38(15-7-9-19(30)18(29)11-15)27(39)34-23(22)33-24(37)16-12-32-26(36(3)4)35-25(16)40-5/h6-13,21H,1-5H3,(H,34,39)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	385	n/a	n/a	n/a	n/a	n/a	25
NOVARTIS AG US Patent					Assay Description Assay 2: For selected compounds displaying IC50s between 0.05 and 5 nM on MDM2, a slightly modified assay is used with the following adaptations: 0.1...				US Patent US9403827 (2016) BindingDB Entry DOI: 10.7270/Q2Z31XKH
					More data for this Ligand-Target Pair