BDBM239240 US9416126, D56

SMILES: CC(C)Oc1cc2c(n[nH]c2cc1F)-c1cc(ncn1)N1CCN(CC1)c1cnn(C)c1

InChI Key: InChIKey=JCMXFBTYHSGSHP-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 239240   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM239240 (US9416126, D56) Show SMILES CC(C)Oc1cc2c(n[nH]c2cc1F)-c1cc(ncn1)N1CCN(CC1)c1cnn(C)c1 Show InChI InChI=1S/C22H25FN8O/c1-14(2)32-20-8-16-18(9-17(20)23)27-28-22(16)19-10-21(25-13-24-19)31-6-4-30(5-7-31)15-11-26-29(3)12-15/h8-14H,4-7H2,1-3H3,(H,27,28)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.19	n/a	n/a	n/a	n/a	8.5	25
Merck Sharp & Dohme Corp. US Patent					Assay Description a) 400 nl of a 1:2.15 serial dilution of test compound(98 μM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well...				US Patent US9416126 (2016) BindingDB Entry DOI: 10.7270/Q2D50KV9
					More data for this Ligand-Target Pair