BDBM24031 (2R)-2-{[4-(4-hydroxyphenyl)benzene]sulfonamido}-3-methylbutanoic acid::biphenylsulfonamide carboxylate, 8
SMILES: CC(C)[C@@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(O)cc1)C(O)=O
InChI Key: InChIKey=PQTZCOOFMGZHKK-MRXNPFEDSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 24031 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4)
(Homo sapiens (Human)) | BDBM24031
![PNG](/data/jpeg/tenK2/BindingDB_24031.png) ((2R)-2-{[4-(4-hydroxyphenyl)benzene]sulfonamido}-3...)Show SMILES CC(C)[C@@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(O)cc1)C(O)=O |r| Show InChI InChI=1S/C17H19NO5S/c1-11(2)16(17(20)21)18-24(22,23)15-9-5-13(6-10-15)12-3-7-14(19)8-4-12/h3-11,16,18-19H,1-2H3,(H,20,21)/t16-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of aggrecanase-1 |
Bioorg Med Chem Lett 21: 6800-3 (2011)
Article DOI: 10.1016/j.bmcl.2011.09.036 BindingDB Entry DOI: 10.7270/Q2BV7H23 |
More data for this Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4)
(Homo sapiens (Human)) | BDBM24031
![PNG](/data/jpeg/tenK2/BindingDB_24031.png) ((2R)-2-{[4-(4-hydroxyphenyl)benzene]sulfonamido}-3...)Show SMILES CC(C)[C@@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(O)cc1)C(O)=O |r| Show InChI InChI=1S/C17H19NO5S/c1-11(2)16(17(20)21)18-24(22,23)15-9-5-13(6-10-15)12-3-7-14(19)8-4-12/h3-11,16,18-19H,1-2H3,(H,20,21)/t16-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4.60E+3 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Wyeth Research
| Assay Description The recombinant Agg-1 proteins pretreated with the various concentrations of the compound for 10 to 15 min. The reaction was initiated by addition of... |
Bioorg Med Chem Lett 16: 311-6 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.001 BindingDB Entry DOI: 10.7270/Q2CJ8BS1 |
More data for this Ligand-Target Pair | |