BDBM240635 US9409882, 40
SMILES: Cn1cc(cn1)-c1ccc(c(Cl)c1)S(=O)(=O)[C@@H]1C[C@H](N(C1)C(=O)C1(CC1)c1ncc(Cl)cc1Cl)C(=O)NC1(CC1)C#N
InChI Key: InChIKey=IPZZWADNXFGPHL-KNQAVFIVSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Procathepsin L (Homo sapiens (Human)) | BDBM240635![]() (US9409882, 40) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 111 | n/a | n/a | n/a | n/a | 6.5 | n/a |
Hoffmann-La Roche Inc. US Patent | Assay Description Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh... | US Patent US9409882 (2016) BindingDB Entry DOI: 10.7270/Q2B56HNF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin S (Homo sapiens (Human)) | BDBM240635![]() (US9409882, 40) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.703 | n/a | n/a | n/a | n/a | 6.5 | n/a |
Hoffmann-La Roche Inc. US Patent | Assay Description Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh... | US Patent US9409882 (2016) BindingDB Entry DOI: 10.7270/Q2B56HNF | |||||||||||
More data for this Ligand-Target Pair |