BDBM241726 US9409917, 23

SMILES: Clc1cc(Cl)c(CNC(=O)C2COc3ncccc23)c(C=C)c1

InChI Key: InChIKey=AOUAOQLBLIAOBQ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 241726   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM241726 (US9409917, 23) Show SMILES Clc1cc(Cl)c(CNC(=O)C2COc3ncccc23)c(C=C)c1 Show InChI InChI=1S/C17H14Cl2N2O2/c1-2-10-6-11(18)7-15(19)13(10)8-21-16(22)14-9-23-17-12(14)4-3-5-20-17/h2-7,14H,1,8-9H2,(H,21,22)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.2	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...				US Patent US9409917 (2016) BindingDB Entry DOI: 10.7270/Q2ZS2VC8
					More data for this Ligand-Target Pair