BDBM241729 US9409917, 26

SMILES: COc1cc(Cl)cc(Cl)c1CNC(=O)C1COc2ncccc12

InChI Key: InChIKey=QNYCUCZHDGLXEE-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 241729   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM241729 (US9409917, 26) Show SMILES COc1cc(Cl)cc(Cl)c1CNC(=O)C1COc2ncccc12 Show InChI InChI=1S/C16H14Cl2N2O3/c1-22-14-6-9(17)5-13(18)11(14)7-20-15(21)12-8-23-16-10(12)3-2-4-19-16/h2-6,12H,7-8H2,1H3,(H,20,21)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	25.6	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...				US Patent US9409917 (2016) BindingDB Entry DOI: 10.7270/Q2ZS2VC8
					More data for this Ligand-Target Pair