BDBM241735 US9409917, 32

SMILES: Fc1ccc(CNC(=O)C2CCOc3ncccc23)c(Cl)c1

InChI Key: InChIKey=RJRVAQBBIXMFOZ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 241735   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM241735 (US9409917, 32) Show SMILES Fc1ccc(CNC(=O)C2CCOc3ncccc23)c(Cl)c1 Show InChI InChI=1S/C16H14ClFN2O2/c17-14-8-11(18)4-3-10(14)9-20-15(21)12-5-7-22-16-13(12)2-1-6-19-16/h1-4,6,8,12H,5,7,9H2,(H,20,21)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...				US Patent US9409917 (2016) BindingDB Entry DOI: 10.7270/Q2ZS2VC8
					More data for this Ligand-Target Pair