BDBM241754 US9409917, 51

SMILES: OCc1cc(Cl)cc(Cl)c1CNC(=O)C1CCOc2ncccc12

InChI Key: InChIKey=ZQJVKJOQFKOGOL-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 241754   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM241754 (US9409917, 51) Show SMILES OCc1cc(Cl)cc(Cl)c1CNC(=O)C1CCOc2ncccc12 Show InChI InChI=1S/C17H16Cl2N2O3/c18-11-6-10(9-22)14(15(19)7-11)8-21-16(23)12-3-5-24-17-13(12)2-1-4-20-17/h1-2,4,6-7,12,22H,3,5,8-9H2,(H,21,23)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.60	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...				US Patent US9409917 (2016) BindingDB Entry DOI: 10.7270/Q2ZS2VC8
					More data for this Ligand-Target Pair