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SMILES: FC(F)(F)c1cccc(CNC(=O)C2(F)COc3ncccc23)c1Cl

InChI Key: InChIKey=NTLMQVKUQKGLEP-UHFFFAOYSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 241758   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
P2X purinoceptor 7


(Homo sapiens (Human))		BDBM241758
PNG
(US9409917, 55)
Show SMILES FC(F)(F)c1cccc(CNC(=O)C2(F)COc3ncccc23)c1Cl
Show InChI InChI=1S/C16H11ClF4N2O2/c17-12-9(3-1-4-10(12)16(19,20)21)7-23-14(24)15(18)8-25-13-11(15)5-2-6-22-13/h1-6H,7-8H2,(H,23,24)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 41.6n/an/an/an/an/a37



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...

US Patent US9409917 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2VC8
More data for this
Ligand-Target Pair