BDBM241762 US9409917, 59::US9409917, 60::US9409917, 81::US9409917, 82::US9409917, 83::US9409917, 84

SMILES: FC(F)(F)c1ncc(cn1)C(CNC(=O)C1COc2ncccc12)N1CCOCC1

InChI Key: InChIKey=ZNKLJUGMIKZITC-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 241762   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM241762 (US9409917, 59 | US9409917, 60 | US9409917, 81 | US...) Show SMILES FC(F)(F)c1ncc(cn1)C(CNC(=O)C1COc2ncccc12)N1CCOCC1 Show InChI InChI=1S/C19H20F3N5O3/c20-19(21,22)18-25-8-12(9-26-18)15(27-4-6-29-7-5-27)10-24-16(28)14-11-30-17-13(14)2-1-3-23-17/h1-3,8-9,14-15H,4-7,10-11H2,(H,24,28)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	346	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...				US Patent US9409917 (2016) BindingDB Entry DOI: 10.7270/Q2ZS2VC8
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM241762 (US9409917, 59 | US9409917, 60 | US9409917, 81 | US...) Show SMILES FC(F)(F)c1ncc(cn1)C(CNC(=O)C1COc2ncccc12)N1CCOCC1 Show InChI InChI=1S/C19H20F3N5O3/c20-19(21,22)18-25-8-12(9-26-18)15(27-4-6-29-7-5-27)10-24-16(28)14-11-30-17-13(14)2-1-3-23-17/h1-3,8-9,14-15H,4-7,10-11H2,(H,24,28)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...				US Patent US9409917 (2016) BindingDB Entry DOI: 10.7270/Q2ZS2VC8
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM241762 (US9409917, 59 | US9409917, 60 | US9409917, 81 | US...) Show SMILES FC(F)(F)c1ncc(cn1)C(CNC(=O)C1COc2ncccc12)N1CCOCC1 Show InChI InChI=1S/C19H20F3N5O3/c20-19(21,22)18-25-8-12(9-26-18)15(27-4-6-29-7-5-27)10-24-16(28)14-11-30-17-13(14)2-1-3-23-17/h1-3,8-9,14-15H,4-7,10-11H2,(H,24,28)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20.8	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...				US Patent US9409917 (2016) BindingDB Entry DOI: 10.7270/Q2ZS2VC8
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM241762 (US9409917, 59 | US9409917, 60 | US9409917, 81 | US...) Show SMILES FC(F)(F)c1ncc(cn1)C(CNC(=O)C1COc2ncccc12)N1CCOCC1 Show InChI InChI=1S/C19H20F3N5O3/c20-19(21,22)18-25-8-12(9-26-18)15(27-4-6-29-7-5-27)10-24-16(28)14-11-30-17-13(14)2-1-3-23-17/h1-3,8-9,14-15H,4-7,10-11H2,(H,24,28)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.23E+3	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...				US Patent US9409917 (2016) BindingDB Entry DOI: 10.7270/Q2ZS2VC8
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM241762 (US9409917, 59 | US9409917, 60 | US9409917, 81 | US...) Show SMILES FC(F)(F)c1ncc(cn1)C(CNC(=O)C1COc2ncccc12)N1CCOCC1 Show InChI InChI=1S/C19H20F3N5O3/c20-19(21,22)18-25-8-12(9-26-18)15(27-4-6-29-7-5-27)10-24-16(28)14-11-30-17-13(14)2-1-3-23-17/h1-3,8-9,14-15H,4-7,10-11H2,(H,24,28)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	124	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...				US Patent US9409917 (2016) BindingDB Entry DOI: 10.7270/Q2ZS2VC8
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM241762 (US9409917, 59 | US9409917, 60 | US9409917, 81 | US...) Show SMILES FC(F)(F)c1ncc(cn1)C(CNC(=O)C1COc2ncccc12)N1CCOCC1 Show InChI InChI=1S/C19H20F3N5O3/c20-19(21,22)18-25-8-12(9-26-18)15(27-4-6-29-7-5-27)10-24-16(28)14-11-30-17-13(14)2-1-3-23-17/h1-3,8-9,14-15H,4-7,10-11H2,(H,24,28)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.52E+3	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...				US Patent US9409917 (2016) BindingDB Entry DOI: 10.7270/Q2ZS2VC8
					More data for this Ligand-Target Pair