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SMILES: FC(F)(F)c1ncc(cn1)C(CNC(=O)C1COc2ncccc12)N1CCC(F)(F)CC1

InChI Key: InChIKey=WKQXOBVXZVHDBY-UHFFFAOYSA-N

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 241765   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
P2X purinoceptor 7


(Homo sapiens (Human))		BDBM241765
PNG
(US9409917, 62)
Show SMILES FC(F)(F)c1ncc(cn1)C(CNC(=O)C1COc2ncccc12)N1CCC(F)(F)CC1
Show InChI InChI=1S/C20H20F5N5O2/c21-19(22)3-6-30(7-4-19)15(12-8-28-18(29-9-12)20(23,24)25)10-27-16(31)14-11-32-17-13(14)2-1-5-26-17/h1-2,5,8-9,14-15H,3-4,6-7,10-11H2,(H,27,31)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 46.9n/an/an/an/an/a37



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...

US Patent US9409917 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2VC8
More data for this
Ligand-Target Pair