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SMILES: COCc1cc(Cl)cc(Cl)c1CNC(=O)C1COc2ncccc12

InChI Key: InChIKey=NETGQGUFXRUGFA-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 241775   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
P2X purinoceptor 7


(Homo sapiens (Human))		BDBM241775
PNG
(US9409917, 72)
Show SMILES COCc1cc(Cl)cc(Cl)c1CNC(=O)C1COc2ncccc12
Show InChI InChI=1S/C17H16Cl2N2O3/c1-23-8-10-5-11(18)6-15(19)13(10)7-21-16(22)14-9-24-17-12(14)3-2-4-20-17/h2-6,14H,7-9H2,1H3,(H,21,22)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 14.6n/an/an/an/an/a37



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...

US Patent US9409917 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2VC8
More data for this
Ligand-Target Pair