BDBM242879 US9427442, 7

SMILES: NC(=O)[C@@H](CC1CC(F)(F)C1)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(OC3CC3)c2NC1=O

InChI Key: InChIKey=SKRPANNVXVGYFB-BNIKKZEQSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 242879   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Notch 3-CBF1 (Homo sapiens (Human))	BDBM242879 (US9427442, 7) Show SMILES NC(=O)[C@@H](CC1CC(F)(F)C1)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(OC3CC3)c2NC1=O |r,t:23| Show InChI InChI=1S/C30H31F5N4O4/c31-29(32)14-16(15-29)13-21(25(36)40)19(11-12-30(33,34)35)27(41)39-26-28(42)38-24-20(7-4-8-22(24)43-18-9-10-18)23(37-26)17-5-2-1-3-6-17/h1-8,16,18-19,21,26H,9-15H2,(H2,36,40)(H,38,42)(H,39,41)/t19-,21+,26-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...				US Patent US9427442 (2016) BindingDB Entry DOI: 10.7270/Q2ZP452P
					More data for this Ligand-Target Pair
Notch 1-CBF1 (Homo sapiens (Human))	BDBM242879 (US9427442, 7) Show SMILES NC(=O)[C@@H](CC1CC(F)(F)C1)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(OC3CC3)c2NC1=O |r,t:23| Show InChI InChI=1S/C30H31F5N4O4/c31-29(32)14-16(15-29)13-21(25(36)40)19(11-12-30(33,34)35)27(41)39-26-28(42)38-24-20(7-4-8-22(24)43-18-9-10-18)23(37-26)17-5-2-1-3-6-17/h1-8,16,18-19,21,26H,9-15H2,(H2,36,40)(H,38,42)(H,39,41)/t19-,21+,26-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.90	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...				US Patent US9427442 (2016) BindingDB Entry DOI: 10.7270/Q2ZP452P
					More data for this Ligand-Target Pair