BDBM243424 7-(5-chloro-4-(2-(isopropylsulfonyl)phenylamino)pyrimidin-2-yl)amino)-6-methoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamide::US10053458, 40

SMILES: COc1cc2CCN(Cc2cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1)S(N)(=O)=O

InChI Key: InChIKey=GUVYVRSFYHAUGS-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 243424   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
ALK tyrosine kinase receptor (Homo sapiens (Human))	BDBM243424 (7-(5-chloro-4-(2-(isopropylsulfonyl)phenylamino)py...) Show SMILES COc1cc2CCN(Cc2cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1)S(N)(=O)=O Show InChI InChI=1S/C23H27ClN6O5S2/c1-14(2)36(31,32)21-7-5-4-6-18(21)27-22-17(24)12-26-23(29-22)28-19-10-16-13-30(37(25,33)34)9-8-15(16)11-20(19)35-3/h4-7,10-12,14H,8-9,13H2,1-3H3,(H2,25,33,34)(H2,26,27,28,29)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	25
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY US Patent					Assay Description A proliferation inhibitory activity against the ALK of the compound represented by Chemical Formula 1 according to the present invention at an enzyme...				US Patent US10053458 (2018) BindingDB Entry DOI: 10.7270/Q2ZS2ZH9
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Homo sapiens (Human))	BDBM243424 (7-(5-chloro-4-(2-(isopropylsulfonyl)phenylamino)py...) Show SMILES COc1cc2CCN(Cc2cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1)S(N)(=O)=O Show InChI InChI=1S/C23H27ClN6O5S2/c1-14(2)36(31,32)21-7-5-4-6-18(21)27-22-17(24)12-26-23(29-22)28-19-10-16-13-30(37(25,33)34)9-8-15(16)11-20(19)35-3/h4-7,10-12,14H,8-9,13H2,1-3H3,(H2,25,33,34)(H2,26,27,28,29)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Homo sapiens (Human))	BDBM243424 (7-(5-chloro-4-(2-(isopropylsulfonyl)phenylamino)py...) Show SMILES COc1cc2CCN(Cc2cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1)S(N)(=O)=O Show InChI InChI=1S/C23H27ClN6O5S2/c1-14(2)36(31,32)21-7-5-4-6-18(21)27-22-17(24)12-26-23(29-22)28-19-10-16-13-30(37(25,33)34)9-8-15(16)11-20(19)35-3/h4-7,10-12,14H,8-9,13H2,1-3H3,(H2,25,33,34)(H2,26,27,28,29)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M) (Homo sapiens (Human))	BDBM243424 (7-(5-chloro-4-(2-(isopropylsulfonyl)phenylamino)py...) Show SMILES COc1cc2CCN(Cc2cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1)S(N)(=O)=O Show InChI InChI=1S/C23H27ClN6O5S2/c1-14(2)36(31,32)21-7-5-4-6-18(21)27-22-17(24)12-26-23(29-22)28-19-10-16-13-30(37(25,33)34)9-8-15(16)11-20(19)35-3/h4-7,10-12,14H,8-9,13H2,1-3H3,(H2,25,33,34)(H2,26,27,28,29)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY US Patent									US Patent US10053458 (2018) BindingDB Entry DOI: 10.7270/Q2ZS2ZH9
					More data for this Ligand-Target Pair