BDBM244140 US9428492, 11a::US9428492, 11b

SMILES: Cc1nc(C(O)C(F)F)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C

InChI Key: InChIKey=FTFOWEVQLMMZLL-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 244140   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM244140 (US9428492, 11a | US9428492, 11b) Show SMILES Cc1nc(C(O)C(F)F)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C Show InChI InChI=1S/C21H22F2N8O/c1-11-24-16(8-17(25-11)31-21(18(32)19(22)23)26-12(2)28-31)30-9-13(10-30)20-27-14-6-4-5-7-15(14)29(20)3/h4-8,13,18-19,32H,9-10H2,1-3H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.650	-12.5	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9428492 (2016) BindingDB Entry DOI: 10.7270/Q2HD7TKM
					More data for this Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM244140 (US9428492, 11a | US9428492, 11b) Show SMILES Cc1nc(C(O)C(F)F)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C Show InChI InChI=1S/C21H22F2N8O/c1-11-24-16(8-17(25-11)31-21(18(32)19(22)23)26-12(2)28-31)30-9-13(10-30)20-27-14-6-4-5-7-15(14)29(20)3/h4-8,13,18-19,32H,9-10H2,1-3H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	3	-11.6	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9428492 (2016) BindingDB Entry DOI: 10.7270/Q2HD7TKM
					More data for this Ligand-Target Pair