BDBM244151 US9428492, 20::US9428492, 20a::US9428492, 20b

SMILES: Cc1nc(C(O)C(F)(F)F)n(n1)-c1cc(nc(C)n1)C1C[C@H]1c1nc2ccccc2n1C

InChI Key: InChIKey=AZVXNJWTMXGGSL-YNAXMUEKSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 244151   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM244151 (US9428492, 20 | US9428492, 20a | US9428492, 20b) Show SMILES Cc1nc(C(O)C(F)(F)F)n(n1)-c1cc(nc(C)n1)C1C[C@H]1c1nc2ccccc2n1C |r| Show InChI InChI=1S/C21H20F3N7O/c1-10-25-15(12-8-13(12)19-28-14-6-4-5-7-16(14)30(19)3)9-17(26-10)31-20(27-11(2)29-31)18(32)21(22,23)24/h4-7,9,12-13,18,32H,8H2,1-3H3/t12?,13-,18?/m1/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.550	-12.6	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9428492 (2016) BindingDB Entry DOI: 10.7270/Q2HD7TKM
					More data for this Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM244151 (US9428492, 20 | US9428492, 20a | US9428492, 20b) Show SMILES Cc1nc(C(O)C(F)(F)F)n(n1)-c1cc(nc(C)n1)C1C[C@H]1c1nc2ccccc2n1C |r| Show InChI InChI=1S/C21H20F3N7O/c1-10-25-15(12-8-13(12)19-28-14-6-4-5-7-16(14)30(19)3)9-17(26-10)31-20(27-11(2)29-31)18(32)21(22,23)24/h4-7,9,12-13,18,32H,8H2,1-3H3/t12?,13-,18?/m1/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.580	-12.6	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9428492 (2016) BindingDB Entry DOI: 10.7270/Q2HD7TKM
					More data for this Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM244151 (US9428492, 20 | US9428492, 20a | US9428492, 20b) Show SMILES Cc1nc(C(O)C(F)(F)F)n(n1)-c1cc(nc(C)n1)C1C[C@H]1c1nc2ccccc2n1C |r| Show InChI InChI=1S/C21H20F3N7O/c1-10-25-15(12-8-13(12)19-28-14-6-4-5-7-16(14)30(19)3)9-17(26-10)31-20(27-11(2)29-31)18(32)21(22,23)24/h4-7,9,12-13,18,32H,8H2,1-3H3/t12?,13-,18?/m1/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.920	-12.3	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9428492 (2016) BindingDB Entry DOI: 10.7270/Q2HD7TKM
					More data for this Ligand-Target Pair