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SMILES: Cc1nc(n(n1)-c1cc(nc(C)n1)C1C[C@H]1c1nc2ccccc2n1C)C(C)(C)O

InChI Key: InChIKey=HMJGDWOLEDIDLX-YSSOQSIOSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 244155   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM244155 (US9428492, A) Show SMILES Cc1nc(n(n1)-c1cc(nc(C)n1)C1C[C@H]1c1nc2ccccc2n1C)C(C)(C)O |r| Show InChI InChI=1S/C22H25N7O/c1-12-23-17(11-19(24-12)29-21(22(3,4)30)25-13(2)27-29)14-10-15(14)20-26-16-8-6-7-9-18(16)28(20)5/h6-9,11,14-15,30H,10H2,1-5H3/t14?,15-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	4.20	-11.4	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9428492 (2016) BindingDB Entry DOI: 10.7270/Q2HD7TKM
					More data for this Ligand-Target Pair
Cytochrome P450 2C9 (Homo sapiens (Human))	BDBM244155 (US9428492, A) Show SMILES Cc1nc(n(n1)-c1cc(nc(C)n1)C1C[C@H]1c1nc2ccccc2n1C)C(C)(C)O |r| Show InChI InChI=1S/C22H25N7O/c1-12-23-17(11-19(24-12)29-21(22(3,4)30)25-13(2)27-29)14-10-15(14)20-26-16-8-6-7-9-18(16)28(20)5/h6-9,11,14-15,30H,10H2,1-5H3/t14?,15-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description Inhibition assay using CYP2C9				US Patent US9428492 (2016) BindingDB Entry DOI: 10.7270/Q2HD7TKM
					More data for this Ligand-Target Pair