null

SMILES: CC(C)c1nc2CCN(CCc2c(Nc2ccc3c(c2)N(C)CCC3(C)C)n1)c1ncccc1C(F)(F)F

InChI Key: InChIKey=VXMBPOXBOYZLMH-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 244934   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM244934 (US9422293, 162 | US9738649, Example 162) Show SMILES CC(C)c1nc2CCN(CCc2c(Nc2ccc3c(c2)N(C)CCC3(C)C)n1)c1ncccc1C(F)(F)F Show InChI InChI=1S/C29H35F3N6/c1-18(2)25-35-23-11-15-38(27-22(29(30,31)32)7-6-13-33-27)14-10-20(23)26(36-25)34-19-8-9-21-24(17-19)37(5)16-12-28(21,3)4/h6-9,13,17-18H,10-12,14-16H2,1-5H3,(H,34,35,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	37
Janssen Pharmaceutica NV US Patent					Assay Description HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...				US Patent US9422293 (2016) BindingDB Entry DOI: 10.7270/Q2P55MD8
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM244934 (US9422293, 162 | US9738649, Example 162) Show SMILES CC(C)c1nc2CCN(CCc2c(Nc2ccc3c(c2)N(C)CCC3(C)C)n1)c1ncccc1C(F)(F)F Show InChI InChI=1S/C29H35F3N6/c1-18(2)25-35-23-11-15-38(27-22(29(30,31)32)7-6-13-33-27)14-10-20(23)26(36-25)34-19-8-9-21-24(17-19)37(5)16-12-28(21,3)4/h6-9,13,17-18H,10-12,14-16H2,1-5H3,(H,34,35,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA N.V. US Patent					Assay Description The assay was performed as described above, using HEK293 cells transfected with rat TRPV1 (rTRPV1/HEK293). These cells had a geneticin selection mark...				US Patent US9738649 (2017) BindingDB Entry DOI: 10.7270/Q2G73GVH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM244934 (US9422293, 162 | US9738649, Example 162) Show SMILES CC(C)c1nc2CCN(CCc2c(Nc2ccc3c(c2)N(C)CCC3(C)C)n1)c1ncccc1C(F)(F)F Show InChI InChI=1S/C29H35F3N6/c1-18(2)25-35-23-11-15-38(27-22(29(30,31)32)7-6-13-33-27)14-10-20(23)26(36-25)34-19-8-9-21-24(17-19)37(5)16-12-28(21,3)4/h6-9,13,17-18H,10-12,14-16H2,1-5H3,(H,34,35,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA N.V. US Patent					Assay Description HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...				US Patent US9738649 (2017) BindingDB Entry DOI: 10.7270/Q2G73GVH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM244934 (US9422293, 162 | US9738649, Example 162) Show SMILES CC(C)c1nc2CCN(CCc2c(Nc2ccc3c(c2)N(C)CCC3(C)C)n1)c1ncccc1C(F)(F)F Show InChI InChI=1S/C29H35F3N6/c1-18(2)25-35-23-11-15-38(27-22(29(30,31)32)7-6-13-33-27)14-10-20(23)26(36-25)34-19-8-9-21-24(17-19)37(5)16-12-28(21,3)4/h6-9,13,17-18H,10-12,14-16H2,1-5H3,(H,34,35,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	37
Janssen Pharmaceutica NV US Patent					Assay Description The assay was performed as described below, using HEK293 cells transfected with rat TRPV1 (rTRPV1/HEK293). These cells had a geneticin selection mark...				US Patent US9422293 (2016) BindingDB Entry DOI: 10.7270/Q2P55MD8
					More data for this Ligand-Target Pair