null

SMILES: COCCN(C)c1nc2CCN(CCc2c(Nc2ccc(cc2)C(C)(C)C)n1)c1ncccc1C(F)(F)F

InChI Key: InChIKey=SMUOBGZHPRFINI-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 245018   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM245018 (US9422293, 257 | US9738649, Example 257) Show SMILES COCCN(C)c1nc2CCN(CCc2c(Nc2ccc(cc2)C(C)(C)C)n1)c1ncccc1C(F)(F)F Show InChI InChI=1S/C28H35F3N6O/c1-27(2,3)19-8-10-20(11-9-19)33-24-21-12-15-37(25-22(28(29,30)31)7-6-14-32-25)16-13-23(21)34-26(35-24)36(4)17-18-38-5/h6-11,14H,12-13,15-18H2,1-5H3,(H,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	37
Janssen Pharmaceutica NV US Patent					Assay Description HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...				US Patent US9422293 (2016) BindingDB Entry DOI: 10.7270/Q2P55MD8
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM245018 (US9422293, 257 | US9738649, Example 257) Show SMILES COCCN(C)c1nc2CCN(CCc2c(Nc2ccc(cc2)C(C)(C)C)n1)c1ncccc1C(F)(F)F Show InChI InChI=1S/C28H35F3N6O/c1-27(2,3)19-8-10-20(11-9-19)33-24-21-12-15-37(25-22(28(29,30)31)7-6-14-32-25)16-13-23(21)34-26(35-24)36(4)17-18-38-5/h6-11,14H,12-13,15-18H2,1-5H3,(H,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA N.V. US Patent					Assay Description The assay was performed as described above, using HEK293 cells transfected with rat TRPV1 (rTRPV1/HEK293). These cells had a geneticin selection mark...				US Patent US9738649 (2017) BindingDB Entry DOI: 10.7270/Q2G73GVH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM245018 (US9422293, 257 | US9738649, Example 257) Show SMILES COCCN(C)c1nc2CCN(CCc2c(Nc2ccc(cc2)C(C)(C)C)n1)c1ncccc1C(F)(F)F Show InChI InChI=1S/C28H35F3N6O/c1-27(2,3)19-8-10-20(11-9-19)33-24-21-12-15-37(25-22(28(29,30)31)7-6-14-32-25)16-13-23(21)34-26(35-24)36(4)17-18-38-5/h6-11,14H,12-13,15-18H2,1-5H3,(H,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA N.V. US Patent					Assay Description HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...				US Patent US9738649 (2017) BindingDB Entry DOI: 10.7270/Q2G73GVH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM245018 (US9422293, 257 | US9738649, Example 257) Show SMILES COCCN(C)c1nc2CCN(CCc2c(Nc2ccc(cc2)C(C)(C)C)n1)c1ncccc1C(F)(F)F Show InChI InChI=1S/C28H35F3N6O/c1-27(2,3)19-8-10-20(11-9-19)33-24-21-12-15-37(25-22(28(29,30)31)7-6-14-32-25)16-13-23(21)34-26(35-24)36(4)17-18-38-5/h6-11,14H,12-13,15-18H2,1-5H3,(H,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	37
Janssen Pharmaceutica NV US Patent					Assay Description The assay was performed as described below, using HEK293 cells transfected with rat TRPV1 (rTRPV1/HEK293). These cells had a geneticin selection mark...				US Patent US9422293 (2016) BindingDB Entry DOI: 10.7270/Q2P55MD8
					More data for this Ligand-Target Pair