null

SMILES: CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(-c4ccc(COc5cccc(c5)C(F)(F)F)cc4)c3c2c1

InChI Key: InChIKey=BYTWENIMWJOMFQ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 245215   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
ALK tyrosine kinase receptor [L1196M] (Homo sapiens (Human))	BDBM245215 (US9428500, 9) Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(-c4ccc(COc5cccc(c5)C(F)(F)F)cc4)c3c2c1 Show InChI InChI=1S/C36H31F3N4O/c1-42-17-19-43(20-18-42)29-12-9-25(10-13-29)27-11-14-33-32(21-27)34-31(15-16-40-35(34)41-33)26-7-5-24(6-8-26)23-44-30-4-2-3-28(22-30)36(37,38)39/h2-16,21-22H,17-20,23H2,1H3,(H,40,41)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	350	n/a	n/a	n/a	n/a	7.5	30
UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON US Patent					Assay Description GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...				US Patent US9428500 (2016) BindingDB Entry DOI: 10.7270/Q2CR5S8M
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Homo sapiens (Human))	BDBM245215 (US9428500, 9) Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(-c4ccc(COc5cccc(c5)C(F)(F)F)cc4)c3c2c1 Show InChI InChI=1S/C36H31F3N4O/c1-42-17-19-43(20-18-42)29-12-9-25(10-13-29)27-11-14-33-32(21-27)34-31(15-16-40-35(34)41-33)26-7-5-24(6-8-26)23-44-30-4-2-3-28(22-30)36(37,38)39/h2-16,21-22H,17-20,23H2,1H3,(H,40,41)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	7.5	30
UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON US Patent					Assay Description GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...				US Patent US9428500 (2016) BindingDB Entry DOI: 10.7270/Q2CR5S8M
					More data for this Ligand-Target Pair