BDBM24527 (2E,5E)-2-(1,3-benzothiazol-2-ylimino)-5-[(4-nitrophenyl)methylidene]-1,3-thiazolidin-4-one::Benzothiazolyl- analogue, 14

SMILES: [O-][N+](=O)c1ccc(\C=C2\S\C(NC2=O)=N\c2nc3ccccc3s2)cc1

InChI Key: InChIKey=KXBLZBZSMUAGFG-NTEUORMPSA-N

Data: 1 KI

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 24527   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM24527 ((2E,5E)-2-(1,3-benzothiazol-2-ylimino)-5-[(4-nitro...) Show SMILES [O-][N+](=O)c1ccc(\C=C2\S\C(NC2=O)=N\c2nc3ccccc3s2)cc1 Show InChI InChI=1S/C17H10N4O3S2/c22-15-14(9-10-5-7-11(8-6-10)21(23)24)26-17(19-15)20-16-18-12-3-1-2-4-13(12)25-16/h1-9H,(H,18,19,20,22)/b14-9+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	1.62E+4	-6.53	n/a	n/a	n/a	n/a	n/a	7.0	25
Aristotle University					Assay Description SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before...				J Med Chem 51: 5221-8 (2008) Article DOI: 10.1021/jm8004306 BindingDB Entry DOI: 10.7270/Q2251GGD
					More data for this Ligand-Target Pair