BDBM24529 (2Z,5E)-2-(1,2-benzothiazol-3-ylimino)-5-[(4-methoxyphenyl)methylidene]-1,3-thiazolidin-4-one::2-(benzo[d]isothiazol-3-ylimino)-5-benzylidenethiazolidin-4-one, 4b::Benzisothiazole analogue, 16
SMILES: COc1ccc(\C=C2\S\C(NC2=O)=N/c2nsc3ccccc23)cc1
InChI Key: InChIKey=CUYKYRMAYZIOKD-XNTDXEJSSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human)) | BDBM24529 ((2Z,5E)-2-(1,2-benzothiazol-3-ylimino)-5-[(4-metho...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 2.28E+4 | -6.33 | n/a | n/a | n/a | n/a | n/a | 7.0 | 25 |
Aristotle University | Assay Description SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before... | J Med Chem 51: 5221-8 (2008) Article DOI: 10.1021/jm8004306 BindingDB Entry DOI: 10.7270/Q2251GGD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Collagenase 3 (Homo sapiens (Human)) | BDBM24529 ((2Z,5E)-2-(1,2-benzothiazol-3-ylimino)-5-[(4-metho...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Technology Curated by ChEMBL | Assay Description Inhibition of MMP13 (unknown origin) | Eur J Med Chem 72: 52-77 (2014) Article DOI: 10.1016/j.ejmech.2013.11.017 BindingDB Entry DOI: 10.7270/Q26M39SV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Collagenase 3 (Homo sapiens (Human)) | BDBM24529 ((2Z,5E)-2-(1,2-benzothiazol-3-ylimino)-5-[(4-metho...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 36 | n/a | n/a | n/a | n/a | 7.0 | 25 |
University of Catania | Assay Description The MMP assay were performed evaluating the ability of compounds 1a-6a and 1b-6b to prevent the hydrolysis of the fluorescence-quenched peptide subst... | Bioorg Chem 39: 48-52 (2011) Article DOI: 10.1016/j.bioorg.2010.11.002 BindingDB Entry DOI: 10.7270/Q28914DM | |||||||||||
More data for this Ligand-Target Pair |