BDBM24539 (3Z)-N-[(4-chlorophenyl)methyl]-3-[2-(2-nitrophenyl)hydrazin-1-ylidene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide::Oxindole scaffold, 10d

SMILES: [O-][N+](=O)c1ccccc1NN=C1C(=O)Nc2ccc(cc12)S(=O)(=O)NCc1ccc(Cl)cc1

InChI Key: InChIKey=AVRGOCDNYXWVMM-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 24539   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein-Tyrosine Phosphatase SHP-2 (Homo sapiens (Human))	BDBM24539 ((3Z)-N-[(4-chlorophenyl)methyl]-3-[2-(2-nitropheny...) Show SMILES [O-][N+](=O)c1ccccc1NN=C1C(=O)Nc2ccc(cc12)S(=O)(=O)NCc1ccc(Cl)cc1 |w:10.10| Show InChI InChI=1S/C21H16ClN5O5S/c22-14-7-5-13(6-8-14)12-23-33(31,32)15-9-10-17-16(11-15)20(21(28)24-17)26-25-18-3-1-2-4-19(18)27(29)30/h1-11,23,25H,12H2,(H,24,26,28)	PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.40E+3	n/a	n/a	n/a	n/a	7.0	22
Moffitt Cancer Center					Assay Description PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...				J Med Chem 51: 4948-56 (2008) Article DOI: 10.1021/jm8002526 BindingDB Entry DOI: 10.7270/Q2XD0ZZ8
					More data for this Ligand-Target Pair
Protein-tyrosine phosphatase 1B (Homo sapiens (Human))	BDBM24539 ((3Z)-N-[(4-chlorophenyl)methyl]-3-[2-(2-nitropheny...) Show SMILES [O-][N+](=O)c1ccccc1NN=C1C(=O)Nc2ccc(cc12)S(=O)(=O)NCc1ccc(Cl)cc1 |w:10.10| Show InChI InChI=1S/C21H16ClN5O5S/c22-14-7-5-13(6-8-14)12-23-33(31,32)15-9-10-17-16(11-15)20(21(28)24-17)26-25-18-3-1-2-4-19(18)27(29)30/h1-11,23,25H,12H2,(H,24,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Moffitt Cancer Center					Assay Description PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...				J Med Chem 51: 4948-56 (2008) Article DOI: 10.1021/jm8002526 BindingDB Entry DOI: 10.7270/Q2XD0ZZ8
					More data for this Ligand-Target Pair
Protein-Tyrosine Phosphatase SHP-1 (Homo sapiens (Human))	BDBM24539 ((3Z)-N-[(4-chlorophenyl)methyl]-3-[2-(2-nitropheny...) Show SMILES [O-][N+](=O)c1ccccc1NN=C1C(=O)Nc2ccc(cc12)S(=O)(=O)NCc1ccc(Cl)cc1 |w:10.10| Show InChI InChI=1S/C21H16ClN5O5S/c22-14-7-5-13(6-8-14)12-23-33(31,32)15-9-10-17-16(11-15)20(21(28)24-17)26-25-18-3-1-2-4-19(18)27(29)30/h1-11,23,25H,12H2,(H,24,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.09E+4	n/a	n/a	n/a	n/a	7.0	22
Moffitt Cancer Center					Assay Description PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...				J Med Chem 51: 4948-56 (2008) Article DOI: 10.1021/jm8002526 BindingDB Entry DOI: 10.7270/Q2XD0ZZ8
					More data for this Ligand-Target Pair