BDBM245507 US9428503, 35

SMILES: CO[C@H]1C[C@H](C1)n1c2c(cnc3ccc(cc23)-c2ccc(OCCCN3CCCC3)nc2)[nH]c1=O

InChI Key:

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 245507   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine-protein kinase ATM (Homo sapiens (Human))	BDBM245507 (US9428503, 35) Show SMILES CO[C@H]1C[C@H](C1)n1c2c(cnc3ccc(cc23)-c2ccc(OCCCN3CCCC3)nc2)[nH]c1=O |r,wD:4.6,2.1,(4.21,4.9,;3.81,3.41,;4.9,2.32,;4.9,.78,;6.44,.78,;6.44,2.32,;7.53,-.31,;7.21,-1.82,;8.54,-2.59,;8.54,-4.13,;7.21,-4.9,;5.88,-4.13,;4.54,-4.9,;3.21,-4.13,;3.21,-2.59,;4.54,-1.82,;5.88,-2.59,;1.87,-1.82,;1.87,-.28,;.54,.49,;-.79,-.28,;-2.13,.49,;-3.46,-.28,;-4.79,.49,;-6.13,-.28,;-7.46,.49,;-7.46,2.03,;-8.93,2.51,;-9.83,1.26,;-8.93,.02,;-.79,-1.82,;.54,-2.59,;9.69,-1.56,;9.06,-.15,;9.83,1.19,)| Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.589	n/a	n/a	n/a	n/a	n/a	37
AstraZeneca AB US Patent					Assay Description Assay a) HT29 cells (ECACC #85061109) were seeded into 384 well assay plates (Costar #3712) at a density of 3500 cells/well in 40 μl EMEM medium c...				US Patent US9428503 (2016) BindingDB Entry DOI: 10.7270/Q2GH9GVJ
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM245507 (US9428503, 35) Show SMILES CO[C@H]1C[C@H](C1)n1c2c(cnc3ccc(cc23)-c2ccc(OCCCN3CCCC3)nc2)[nH]c1=O |r,wD:4.6,2.1,(4.21,4.9,;3.81,3.41,;4.9,2.32,;4.9,.78,;6.44,.78,;6.44,2.32,;7.53,-.31,;7.21,-1.82,;8.54,-2.59,;8.54,-4.13,;7.21,-4.9,;5.88,-4.13,;4.54,-4.9,;3.21,-4.13,;3.21,-2.59,;4.54,-1.82,;5.88,-2.59,;1.87,-1.82,;1.87,-.28,;.54,.49,;-.79,-.28,;-2.13,.49,;-3.46,-.28,;-4.79,.49,;-6.13,-.28,;-7.46,.49,;-7.46,2.03,;-8.93,2.51,;-9.83,1.26,;-8.93,.02,;-.79,-1.82,;.54,-2.59,;9.69,-1.56,;9.06,-.15,;9.83,1.19,)| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	579	n/a	n/a	n/a	n/a	n/a	37
AstraZeneca AB US Patent					Assay Description Assay d) MDA-MB-468 cells (human breast adenocarcinoma ##ATCC HTB 132) were seeded at 1500 cells/well in 40 μl of DMEM containing 10% FBS and 1% g...				US Patent US9428503 (2016) BindingDB Entry DOI: 10.7270/Q2GH9GVJ
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM245507 (US9428503, 35) Show SMILES CO[C@H]1C[C@H](C1)n1c2c(cnc3ccc(cc23)-c2ccc(OCCCN3CCCC3)nc2)[nH]c1=O |r,wD:4.6,2.1,(4.21,4.9,;3.81,3.41,;4.9,2.32,;4.9,.78,;6.44,.78,;6.44,2.32,;7.53,-.31,;7.21,-1.82,;8.54,-2.59,;8.54,-4.13,;7.21,-4.9,;5.88,-4.13,;4.54,-4.9,;3.21,-4.13,;3.21,-2.59,;4.54,-1.82,;5.88,-2.59,;1.87,-1.82,;1.87,-.28,;.54,.49,;-.79,-.28,;-2.13,.49,;-3.46,-.28,;-4.79,.49,;-6.13,-.28,;-7.46,.49,;-7.46,2.03,;-8.93,2.51,;-9.83,1.26,;-8.93,.02,;-.79,-1.82,;.54,-2.59,;9.69,-1.56,;9.06,-.15,;9.83,1.19,)| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	37
AstraZeneca AB US Patent					Assay Description Assay c) BT474 cells (human breast ductal carcinoma, ATCC HTB-20) were seeded into black 384 well plates (Costar, #3712) at a density of 5600 cells/w...				US Patent US9428503 (2016) BindingDB Entry DOI: 10.7270/Q2GH9GVJ
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase ATR (Homo sapiens (Human))	BDBM245507 (US9428503, 35) Show SMILES CO[C@H]1C[C@H](C1)n1c2c(cnc3ccc(cc23)-c2ccc(OCCCN3CCCC3)nc2)[nH]c1=O |r,wD:4.6,2.1,(4.21,4.9,;3.81,3.41,;4.9,2.32,;4.9,.78,;6.44,.78,;6.44,2.32,;7.53,-.31,;7.21,-1.82,;8.54,-2.59,;8.54,-4.13,;7.21,-4.9,;5.88,-4.13,;4.54,-4.9,;3.21,-4.13,;3.21,-2.59,;4.54,-1.82,;5.88,-2.59,;1.87,-1.82,;1.87,-.28,;.54,.49,;-.79,-.28,;-2.13,.49,;-3.46,-.28,;-4.79,.49,;-6.13,-.28,;-7.46,.49,;-7.46,2.03,;-8.93,2.51,;-9.83,1.26,;-8.93,.02,;-.79,-1.82,;.54,-2.59,;9.69,-1.56,;9.06,-.15,;9.83,1.19,)| Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.78E+4	n/a	n/a	n/a	n/a	n/a	37
AstraZeneca AB US Patent					Assay Description Assay b) HT29 cells (ECACC #85061109) were seeded into 384 well assay plates (Costar #3712) at a density of 6000 cells/well in 40 μl EMEM medium c...				US Patent US9428503 (2016) BindingDB Entry DOI: 10.7270/Q2GH9GVJ
					More data for this Ligand-Target Pair