BDBM24552 4-{2-[(3Z)-5-({[4-chloro-3-(trifluoromethyl)phenyl]methyl}sulfamoyl)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]hydrazin-1-yl}benzoic acid::Oxindole scaffold, 10q

SMILES: OC(=O)c1ccc(NN=C2C(=O)Nc3ccc(cc23)S(=O)(=O)NCc2ccc(Cl)c(c2)C(F)(F)F)cc1

InChI Key: InChIKey=VAMIHNZRXGILMF-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 24552   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein-Tyrosine Phosphatase SHP-2 (Homo sapiens (Human))	BDBM24552 (4-{2-[(3Z)-5-({[4-chloro-3-(trifluoromethyl)phenyl...) Show SMILES OC(=O)c1ccc(NN=C2C(=O)Nc3ccc(cc23)S(=O)(=O)NCc2ccc(Cl)c(c2)C(F)(F)F)cc1 |w:8.7| Show InChI InChI=1S/C23H16ClF3N4O5S/c24-18-7-1-12(9-17(18)23(25,26)27)11-28-37(35,36)15-6-8-19-16(10-15)20(21(32)29-19)31-30-14-4-2-13(3-5-14)22(33)34/h1-10,28,30H,11H2,(H,33,34)(H,29,31,32)	PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.30E+3	n/a	n/a	n/a	n/a	7.0	22
Moffitt Cancer Center					Assay Description PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...				J Med Chem 51: 4948-56 (2008) Article DOI: 10.1021/jm8002526 BindingDB Entry DOI: 10.7270/Q2XD0ZZ8
					More data for this Ligand-Target Pair
Protein-tyrosine phosphatase 1B (Homo sapiens (Human))	BDBM24552 (4-{2-[(3Z)-5-({[4-chloro-3-(trifluoromethyl)phenyl...) Show SMILES OC(=O)c1ccc(NN=C2C(=O)Nc3ccc(cc23)S(=O)(=O)NCc2ccc(Cl)c(c2)C(F)(F)F)cc1 |w:8.7| Show InChI InChI=1S/C23H16ClF3N4O5S/c24-18-7-1-12(9-17(18)23(25,26)27)11-28-37(35,36)15-6-8-19-16(10-15)20(21(32)29-19)31-30-14-4-2-13(3-5-14)22(33)34/h1-10,28,30H,11H2,(H,33,34)(H,29,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.28E+4	n/a	n/a	n/a	n/a	n/a	n/a
Moffitt Cancer Center					Assay Description PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...				J Med Chem 51: 4948-56 (2008) Article DOI: 10.1021/jm8002526 BindingDB Entry DOI: 10.7270/Q2XD0ZZ8
					More data for this Ligand-Target Pair
Protein-Tyrosine Phosphatase SHP-1 (Homo sapiens (Human))	BDBM24552 (4-{2-[(3Z)-5-({[4-chloro-3-(trifluoromethyl)phenyl...) Show SMILES OC(=O)c1ccc(NN=C2C(=O)Nc3ccc(cc23)S(=O)(=O)NCc2ccc(Cl)c(c2)C(F)(F)F)cc1 |w:8.7| Show InChI InChI=1S/C23H16ClF3N4O5S/c24-18-7-1-12(9-17(18)23(25,26)27)11-28-37(35,36)15-6-8-19-16(10-15)20(21(32)29-19)31-30-14-4-2-13(3-5-14)22(33)34/h1-10,28,30H,11H2,(H,33,34)(H,29,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.31E+4	n/a	n/a	n/a	n/a	n/a	n/a
Moffitt Cancer Center					Assay Description PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...				J Med Chem 51: 4948-56 (2008) Article DOI: 10.1021/jm8002526 BindingDB Entry DOI: 10.7270/Q2XD0ZZ8
					More data for this Ligand-Target Pair