BDBM246015 US9433622, DMX- 111

SMILES: F[C@@H]1CCN(C1)c1ncc(cc1C#N)-c1ccnc(Nc2ccnc(NC(=O)CN3CCOCC3)c2)n1

InChI Key: InChIKey=INNNCZDYXKUHLV-LJQANCHMSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 246015   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (Homo sapiens (Human))	BDBM246015 (US9433622, DMX- 111) Show SMILES F[C@@H]1CCN(C1)c1ncc(cc1C#N)-c1ccnc(Nc2ccnc(NC(=O)CN3CCOCC3)c2)n1 |r| Show InChI InChI=1S/C25H26FN9O2/c26-19-3-6-35(15-19)24-17(13-27)11-18(14-30-24)21-2-5-29-25(32-21)31-20-1-4-28-22(12-20)33-23(36)16-34-7-9-37-10-8-34/h1-2,4-5,11-12,14,19H,3,6-10,15-16H2,(H2,28,29,31,32,33,36)/t19-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	7.5	n/a
Case Western Reserve University US Patent					Assay Description Kinase inhibition assays (10 μL) were performed at 20° C. in 384-well plate format. Compound IC50 values were determined at the apparent Km for ...				US Patent US9433622 (2016) BindingDB Entry DOI: 10.7270/Q2PZ57R4
					More data for this Ligand-Target Pair
Protein cereblon/Serine/threonine-protein kinase TBK1 (Homo sapiens (Human))	BDBM246015 (US9433622, DMX- 111) Show SMILES F[C@@H]1CCN(C1)c1ncc(cc1C#N)-c1ccnc(Nc2ccnc(NC(=O)CN3CCOCC3)c2)n1 |r| Show InChI InChI=1S/C25H26FN9O2/c26-19-3-6-35(15-19)24-17(13-27)11-18(14-30-24)21-2-5-29-25(32-21)31-20-1-4-28-22(12-20)33-23(36)16-34-7-9-37-10-8-34/h1-2,4-5,11-12,14,19H,3,6-10,15-16H2,(H2,28,29,31,32,33,36)/t19-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<15	n/a	n/a	n/a	n/a	7.5	n/a
Case Western Reserve University US Patent					Assay Description Kinase inhibition assays (10 μL) were performed at 20° C. in 384-well plate format. Compound IC50 values were determined at the apparent Km for ...				US Patent US9433622 (2016) BindingDB Entry DOI: 10.7270/Q2PZ57R4
					More data for this Ligand-Target Pair