BDBM246029 US9433622, DMX- 126

SMILES: F[C@H]1CCN(C1)c1ncc(cc1C#N)-c1ccnc(Nc2ccc3CNCc3c2)n1

InChI Key: InChIKey=KTNKDCBLBAGWEI-SFHVURJKSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 246029   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (Homo sapiens (Human))	BDBM246029 (US9433622, DMX- 126) Show SMILES F[C@H]1CCN(C1)c1ncc(cc1C#N)-c1ccnc(Nc2ccc3CNCc3c2)n1 |r| Show InChI InChI=1S/C22H20FN7/c23-18-4-6-30(13-18)21-15(9-24)7-17(12-27-21)20-3-5-26-22(29-20)28-19-2-1-14-10-25-11-16(14)8-19/h1-3,5,7-8,12,18,25H,4,6,10-11,13H2,(H,26,28,29)/t18-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<15	n/a	n/a	n/a	n/a	7.5	n/a
Case Western Reserve University US Patent					Assay Description Kinase inhibition assays (10 μL) were performed at 20° C. in 384-well plate format. Compound IC50 values were determined at the apparent Km for ...				US Patent US9433622 (2016) BindingDB Entry DOI: 10.7270/Q2PZ57R4
					More data for this Ligand-Target Pair
Protein cereblon/Serine/threonine-protein kinase TBK1 (Homo sapiens (Human))	BDBM246029 (US9433622, DMX- 126) Show SMILES F[C@H]1CCN(C1)c1ncc(cc1C#N)-c1ccnc(Nc2ccc3CNCc3c2)n1 |r| Show InChI InChI=1S/C22H20FN7/c23-18-4-6-30(13-18)21-15(9-24)7-17(12-27-21)20-3-5-26-22(29-20)28-19-2-1-14-10-25-11-16(14)8-19/h1-3,5,7-8,12,18,25H,4,6,10-11,13H2,(H,26,28,29)/t18-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<15	n/a	n/a	n/a	n/a	7.5	n/a
Case Western Reserve University US Patent					Assay Description Kinase inhibition assays (10 μL) were performed at 20° C. in 384-well plate format. Compound IC50 values were determined at the apparent Km for ...				US Patent US9433622 (2016) BindingDB Entry DOI: 10.7270/Q2PZ57R4
					More data for this Ligand-Target Pair