null

SMILES: CN1C(=O)CCc2cc(c(F)cc12)-c1cncc(COc2ncccc2F)c1

InChI Key: InChIKey=FTOABUIBYNWPLJ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 249231   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cytochrome P450 11B1, mitochondrial (Homo sapiens (Human))	BDBM249231 (US9458135, 19) Show SMILES CN1C(=O)CCc2cc(c(F)cc12)-c1cncc(COc2ncccc2F)c1 Show InChI InChI=1S/C21H17F2N3O2/c1-26-19-9-18(23)16(8-14(19)4-5-20(26)27)15-7-13(10-24-11-15)12-28-21-17(22)3-2-6-25-21/h2-3,6-11H,4-5,12H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	997	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Herein we identified the use of the G-402 cell line as a host cell to ectopically express (transiently or stably) enzymes of the CYP11 family. Specif...				US Patent US9458135 (2016) BindingDB Entry DOI: 10.7270/Q2KW5F04
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM249231 (US9458135, 19) Show SMILES CN1C(=O)CCc2cc(c(F)cc12)-c1cncc(COc2ncccc2F)c1 Show InChI InChI=1S/C21H17F2N3O2/c1-26-19-9-18(23)16(8-14(19)4-5-20(26)27)15-7-13(10-24-11-15)12-28-21-17(22)3-2-6-25-21/h2-3,6-11H,4-5,12H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	14.1	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description Herein we identified the use of the G-402 cell line as a host cell to ectopically express (transiently or stably) enzymes of the CYP11 family. Specif...				US Patent US9458135 (2016) BindingDB Entry DOI: 10.7270/Q2KW5F04
					More data for this Ligand-Target Pair