BDBM249331 US10300060, Example 15-63::US10765676, Example 15-63::US9463192, 15-63::US9763943, 15-63::US9993479, 15-63

SMILES: Nc1ncc(Cl)cc1-c1ccc(Oc2ncc(NC(=O)Nc3cc(ccc3-n3cc(Cl)cn3)C(F)(F)F)cn2)cc1

InChI Key: InChIKey=COGIMTBAFAQCIC-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 249331   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249331 (US10300060, Example 15-63 | US10765676, Example 15...) Show SMILES Nc1ncc(Cl)cc1-c1ccc(Oc2ncc(NC(=O)Nc3cc(ccc3-n3cc(Cl)cn3)C(F)(F)F)cn2)cc1 Show InChI InChI=1S/C26H17Cl2F3N8O2/c27-16-8-20(23(32)33-9-16)14-1-4-19(5-2-14)41-25-34-11-18(12-35-25)37-24(40)38-21-7-15(26(29,30)31)3-6-22(21)39-13-17(28)10-36-39/h1-13H,(H2,32,33)(H2,37,38,40)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	37
ONO PHARMACEUTICAL CO., LTD. US Patent					Assay Description On the day before the assay, CellSenser TrkA-NFAT-bla CHO-K1 cells were suspended in an assay medium (Opti-MEM1 Reduced Serum Medium (Invitrogen) con...				US Patent US9463192 (2016) BindingDB Entry DOI: 10.7270/Q22Z14FR
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249331 (US10300060, Example 15-63 | US10765676, Example 15...) Show SMILES Nc1ncc(Cl)cc1-c1ccc(Oc2ncc(NC(=O)Nc3cc(ccc3-n3cc(Cl)cn3)C(F)(F)F)cn2)cc1 Show InChI InChI=1S/C26H17Cl2F3N8O2/c27-16-8-20(23(32)33-9-16)14-1-4-19(5-2-14)41-25-34-11-18(12-35-25)37-24(40)38-21-7-15(26(29,30)31)3-6-22(21)39-13-17(28)10-36-39/h1-13H,(H2,32,33)(H2,37,38,40)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
ONO PHARMACEUTICAL CO., LTD. US Patent					Assay Description On the day before the assay, CellSenser TrkA-NFAT-bla CHO-K1 cells were suspended in an assay medium (Opti-MEM1 Reduced Serum Medium (Invitrogen) con...				US Patent US9763943 (2017) BindingDB Entry DOI: 10.7270/Q2ZW1P0X
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249331 (US10300060, Example 15-63 | US10765676, Example 15...) Show SMILES Nc1ncc(Cl)cc1-c1ccc(Oc2ncc(NC(=O)Nc3cc(ccc3-n3cc(Cl)cn3)C(F)(F)F)cn2)cc1 Show InChI InChI=1S/C26H17Cl2F3N8O2/c27-16-8-20(23(32)33-9-16)14-1-4-19(5-2-14)41-25-34-11-18(12-35-25)37-24(40)38-21-7-15(26(29,30)31)3-6-22(21)39-13-17(28)10-36-39/h1-13H,(H2,32,33)(H2,37,38,40)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
ONO PHARMACEUTICAL CO., LTD. US Patent					Assay Description On the day before the assay, CellSenser TrkA-NFAT-bla CHO-K1 cells were suspended in an assay medium (Opti-MEM1 Reduced Serum Medium (Invitrogen) con...				US Patent US10765676 (2020)
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249331 (US10300060, Example 15-63 | US10765676, Example 15...) Show SMILES Nc1ncc(Cl)cc1-c1ccc(Oc2ncc(NC(=O)Nc3cc(ccc3-n3cc(Cl)cn3)C(F)(F)F)cn2)cc1 Show InChI InChI=1S/C26H17Cl2F3N8O2/c27-16-8-20(23(32)33-9-16)14-1-4-19(5-2-14)41-25-34-11-18(12-35-25)37-24(40)38-21-7-15(26(29,30)31)3-6-22(21)39-13-17(28)10-36-39/h1-13H,(H2,32,33)(H2,37,38,40)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd					Assay Description On the day before the assay, CellSenser™ TrkA-NFAT-b1a CHO-K1 cells were suspended in an assay medium (Opti-MEM1 Reduced Serum Medium (Invitrogen) co...				Bioorg Med Chem Lett 19: 1654-7 (2009) BindingDB Entry DOI: 10.7270/Q2JH3PGF
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249331 (US10300060, Example 15-63 | US10765676, Example 15...) Show SMILES Nc1ncc(Cl)cc1-c1ccc(Oc2ncc(NC(=O)Nc3cc(ccc3-n3cc(Cl)cn3)C(F)(F)F)cn2)cc1 Show InChI InChI=1S/C26H17Cl2F3N8O2/c27-16-8-20(23(32)33-9-16)14-1-4-19(5-2-14)41-25-34-11-18(12-35-25)37-24(40)38-21-7-15(26(29,30)31)3-6-22(21)39-13-17(28)10-36-39/h1-13H,(H2,32,33)(H2,37,38,40)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd.					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				Bioorg Med Chem 17: 2017-29 (2009) BindingDB Entry DOI: 10.7270/Q2WD42WT
					More data for this Ligand-Target Pair