BDBM249479 US9434727, 77
SMILES: Fc1cccc(C2CCN(CC2)C(=O)c2n[nH]c3CN(CCc23)C#N)c1C(F)(F)F
InChI Key: InChIKey=ZYYHTMQCCRJZEY-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Retinol-binding protein 4 (Homo sapiens (Human)) | BDBM249479 (US9434727, 77) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.62 | n/a | n/a | n/a | n/a | 7.5 | 4 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK US Patent | Assay Description TR-FRET assay for retinol-induced RBP4-TTR interaction Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR inte... | US Patent US9434727 (2016) BindingDB Entry DOI: 10.7270/Q2F76BGR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinol-binding protein 4 (Homo sapiens (Human)) | BDBM249479 (US9434727, 77) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.88 | n/a | n/a | n/a | n/a | 7.4 | 4 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK US Patent | Assay Description Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u... | US Patent US9434727 (2016) BindingDB Entry DOI: 10.7270/Q2F76BGR | |||||||||||
More data for this Ligand-Target Pair |