BDBM251641 US9453031, 78
SMILES: COc1cc(-c2nc3N4CCOC[C@H]4COc3c(n2)C2(CCC2)S(C)(=O)=O)c2cc[nH]c2c1
InChI Key:
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serine/threonine-protein kinase mTOR (Homo sapiens (Human)) | BDBM251641 (US9453031, 78) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 47 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Fundación Centro Nacional de Investigaciones Oncológicas Carlos III US Patent | Assay Description The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ... | US Patent US9453031 (2016) BindingDB Entry DOI: 10.7270/Q27H1HH8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
p110α/p85α (Homo sapiens (Human)) | BDBM251641 (US9453031, 78) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.49E+3 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Fundación Centro Nacional de Investigaciones Oncológicas Carlos III US Patent | Assay Description The kinase activity was measured by using the commercial ADP Hunter Plus assay available from DiscoveRx (#33-016), which is a homogeneous assay to me... | US Patent US9453031 (2016) BindingDB Entry DOI: 10.7270/Q27H1HH8 | |||||||||||
More data for this Ligand-Target Pair |